6H05 (TFA)

6H05 TFA is a selective, and allosteric inhibitor of oncogenic mutant K-Ras (G12C) . IC50 value: Target: K-Ras G12C 6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras [1]. 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras (G12C) inhibitors [2].