6H05 (TFA)

6H05 TFA is a selective, and allosteric inhibitor of oncogenic mutant K-Ras (G12C) . IC50 value: Target: K-Ras G12C 6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras [1]. 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras (G12C) inhibitors [2].

Product Specifications

CAS Number

[2061344-88-3]

UNSPSC

12352005

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/6H05-trifluoroacetate.html

Purity

99.02

Solubility

DMSO : ≥ 51 mg/mL|H2O : ≥ 100 mg/mL

Smiles

O=C(C1CCN(C(CSC2=CC=C(Cl)C=C2)=O)CC1)NCCSSCCN(C)C.O=C(O)C(F)(F)F

Molecular Formula

C22H31ClF3N3O4S3

Molecular Weight

590.14

References & Citations

[1]Ostrem JM, et al. K-Ras (G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503 (7477) :548-51.|[2]Lu S, et al. Harnessing allostery: a novel approach to drug discovery. Med Res Rev. 2014 Nov;34 (6) :1242-85.