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DRP1i27 (dihydrochloride)

DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1) . DRP1i27 dihydrochloride binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 dihydrochloride targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury[1].

Product Specifications

UNSPSC

12352005

Target

Dynamin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/drp1i27-dihydrochloride.html

Purity

99.07

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

[H]Cl.CC1=C(NC=N1)CN2C[C@@H]3CC[C@@H](N(C3)CC4=CC=C(O4)C5=NNC=C5)C2.[H]Cl

Molecular Formula

C20H28Cl2N6O

Molecular Weight

439.38

References & Citations

[1]Rosdah AA, et al. A novel small molecule inhibitor of human Drp1. Sci Rep. 2022 Dec 13;12 (1) :21531.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

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