DRP1i27 (dihydrochloride)
Product Specifications
UNSPSC Description
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 dihydrochloride binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 dihydrochloride targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury[1].
Target Antigen
Dynamin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/drp1i27-dihydrochloride.html
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
[H]Cl.CC1=C(NC=N1)CN2C[C@@H]3CC[C@@H](N(C3)CC4=CC=C(O4)C5=NNC=C5)C2.[H]Cl
Molecular Weight
439.38
References & Citations
[1]Rosdah AA, et al. A novel small molecule inhibitor of human Drp1. Sci Rep. 2022 Dec 13;12(1):21531.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-152086A/DRP1i27-dihydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-152086A/DRP1i27-dihydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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