DRP1i27 (dihydrochloride)
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1) . DRP1i27 dihydrochloride binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 dihydrochloride targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury[1].
Product Specifications
UNSPSC
12352005
Target
Dynamin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/drp1i27-dihydrochloride.html
Purity
99.07
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
[H]Cl.CC1=C(NC=N1)CN2C[C@@H]3CC[C@@H](N(C3)CC4=CC=C(O4)C5=NNC=C5)C2.[H]Cl
Molecular Formula
C20H28Cl2N6O
Molecular Weight
439.38
References & Citations
[1]Rosdah AA, et al. A novel small molecule inhibitor of human Drp1. Sci Rep. 2022 Dec 13;12 (1) :21531.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Browse additional items from our catalog
SCGB3A1 (Secretoglobin Family 3A Member 1, Cytokine HIN-1, High in Normal 1, HIN1, HIN-1, LU105, Pneumo Secretory Protein 2, PNSP2, PnSP-2, UNQ629/PRO1245, Uteroglobin-related Protein 2, UGRP2) (MaxLight 750) discontinued
FABP4 Protein, Mouse, Recombinant (His Tag)
