P38α inhibitor 2

P38α inhibitor 2 is a highly potent and selective p38α MAPK inhibitor, with a pIC50 of 9.6. p38α inhibitor 2 inhibits the hERG ion channel (IC50=27 μM) and shows a promising selectivity profile when tested in a panel of 51 other protein kinases ([1].

Product Specifications

CAS Number

[1095003-80-7]

UNSPSC

12352005

Target

P38 MAPK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/p38α-inhibitor-2.html

Purity

98.03

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NC1CC1)C2=CC=C(C)C(N3C(C(NC(C4=CC=CC=C4OCCNC)(C)C)=NC=C3)=O)=C2

Molecular Formula

C27H33N5O3

Molecular Weight

475.58

References & Citations

[1]Raubo P, et al. The discovery and evaluation of 3-amino-2 (1H) -pyrazinones as a novel series of selective p38α MAP kinase inhibitors [published online ahead of print, 2020 Jul 15]. Bioorg Med Chem Lett. 2020;30 (18) :127412.