P38α inhibitor 2
P38α inhibitor 2 is a highly potent and selective p38α MAPK inhibitor, with a pIC50 of 9.6. p38α inhibitor 2 inhibits the hERG ion channel (IC50=27 μM) and shows a promising selectivity profile when tested in a panel of 51 other protein kinases ([1].
Product Specifications
CAS Number
1095003-80-7
UNSPSC
12352005
Target
P38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/p38α-inhibitor-2.html
Purity
98.03
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(NC1CC1)C2=CC=C(C)C(N3C(C(NC(C4=CC=CC=C4OCCNC)(C)C)=NC=C3)=O)=C2
Molecular Formula
C27H33N5O3
Molecular Weight
475.58
References & Citations
[1]Raubo P, et al. The discovery and evaluation of 3-amino-2 (1H) -pyrazinones as a novel series of selective p38α MAP kinase inhibitors [published online ahead of print, 2020 Jul 15]. Bioorg Med Chem Lett. 2020;30 (18) :127412.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P38α
Available Sizes
Frequently Asked Questions
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