Alpha-cobratoxin
α-cobratoxin (alpha-elapitoxin-Nk2a) has been isolated from the venom of the Naja kaouthia cobra snake. α-cobratoxin preferentially blocks muscular and neuronal α 7/CHRNA7 nicotinic acetylcholine receptor (Kd = 55 pM) . α-cobratoxin is involved in paralysis by preventing acetylcholine binding to the nAChR. This toxin has shown to cause reduction of tumor growth in mice lung cancer.
Product Specifications
Specifications
α7 nicotinic acetylcholine receptor (nAChR) antagonist
Target
Acetylcholine receptors
Sequence
IRCFITPDITSKDCPNGHVCYTKTWCDAFCSIRGKRVDLGCAATCPTVKTGVDIQCCSTDNCNPFPTRKRP
Peptide Number
CBT001
Disulfide Bonds
Cys3-Cys20; Cys14-Cys41; Cys26-Cys30; Cys45-Cys56; Cys57-Cys62
N Terminal Sequence
H
C Terminal Sequence
OH
CAS Number
769933-79-1
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