Saruparib

Saruparib (AZD5305) is a potent, orally active and selective PARP inhibitor and trapper with IC50 values of 3 nM and 1400 nM for PARP1 and PARP2, respectively. Saruparib has anti-proliferative activity and inhibits growth in cells with deficiencies in DNA repair[1][2].

Product Specifications

CAS Number

[2589531-76-8]

Product Name Alternative

AZD5305

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/saruparib.html

Concentration

10mM

Purity

99.76

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=NC=C(N2CCN(CC3=CC(N4)=C(N=C3)C=C(CC)C4=O)CC2)C=C1)NC

Molecular Formula

C22H26N6O2

Molecular Weight

406.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Illuzzi G, et, al. Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper. Clin Cancer Res. 2022 Nov 1;28 (21) :4724-4736.|[2]Johannes JW, et, al. Discovery of 5-{4-[ (7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl) methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305) : A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs. J Med Chem. 2021 Oct 14;64 (19) :14498-14512.