Zanamivir

Zanamivir is an influenza viral neuraminidase inhibitor with IC50 values of 0.95 nM and 2.7 nM for influenza A and B, respectively.

Product Specifications

CAS Number

[139110-80-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Influenza Virus

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Zanamivir.html

Purity

99.92

Solubility

H2O : ≥ 33.33 mg/mL

Smiles

NC(N[C@@H]1[C@H]([C@@]([H])(OC(C(O)=O)=C1)[C@@H]([C@@H](CO)O)O)NC(C)=O)=N

Molecular Formula

C12H20N4O7

Molecular Weight

332.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Gubareva LV, et al. Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates ofinfluenza virus and neuraminidase inhibitor-resistant variants. Antimicrob Agents Chemother. 2001 Dec;45 (12) :3403-8.|[2]McKimm-Breschkin JL, et al. Management of influenza virus infections with neuraminidase inhibitors: detection, incidence, and implications of drug resistance. Treat Respir Med. 2005;4 (2) :107-16.|[3]Shanmugam S, et al. Zanamivir oral delivery: enhanced plasma and lung bioavailability in rats. Biomol Ther (Seoul) . 2013 Mar;21 (2) :161-9.