BBT594
BBT594 is a potent receptor tyrosine kinase RET inhibitor, used for cancer treatment.
Product Specifications
CAS Number
882405-89-2
Product Name Alternative
NVP-BBT594
UNSPSC
12352005
Hazard Statement
H315, H317, H318, H334, H335, H341, H361, H370, H413
Target
RET
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BBT594.html
Concentration
10mM
Purity
99.81
Solubility
DMSO : ≥ 33 mg/mL
Smiles
O=C(N1CCC2=C1C=CC(OC3=NC=NC(NC(C)=O)=C3)=C2)NC4=CC=C(CN5CCN(C)CC5)C(C(F)(F)F)=C4
Molecular Formula
C28H30F3N7O3
Molecular Weight
569.58
Precautions
H315, H317, H318, H334, H335, H341, H361, H370, H413
References & Citations
[1]Morandi A, et al. GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors. Cancer Res. 2013 Jun 15;73 (12) :3783-95|[2]Andreucci E, et al. Targeting the receptor tyrosine kinase RET in combination with aromatase inhibitors in ER positive breast cancer xenografts. Oncotarget. 2016 Sep 2. doi: 10.18632/oncotarget.11826. [Epub ahead of print]
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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