BBT594

BBT594 is a potent receptor tyrosine kinase RET inhibitor, used for cancer treatment.

Product Specifications

CAS Number

[882405-89-2]

Product Name Alternative

NVP-BBT594

UNSPSC

12352005

Hazard Statement

H315, H317, H318, H334, H335, H341, H361, H370, H413

Target

RET

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/BBT594.html

Concentration

10mM

Purity

99.81

Solubility

DMSO : ≥ 33 mg/mL

Smiles

O=C(N1CCC2=C1C=CC(OC3=NC=NC(NC(C)=O)=C3)=C2)NC4=CC=C(CN5CCN(C)CC5)C(C(F)(F)F)=C4

Molecular Formula

C28H30F3N7O3

Molecular Weight

569.58

Precautions

H315, H317, H318, H334, H335, H341, H361, H370, H413

References & Citations

[1]Morandi A, et al. GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors. Cancer Res. 2013 Jun 15;73 (12) :3783-95|[2]Andreucci E, et al. Targeting the receptor tyrosine kinase RET in combination with aromatase inhibitors in ER positive breast cancer xenografts. Oncotarget. 2016 Sep 2. doi: 10.18632/oncotarget.11826. [Epub ahead of print]