ETP-46464
ETP-46464 is an effective mTOR and ATR inhibitor with IC50s of 0.6 and 14 nM, respectively.
Product Specifications
CAS Number
1345675-02-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ATM/ATR; mTOR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/etp-46464.html
Purity
99.54
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
O=C1N(C2=CC=C(C(C)(C#N)C)C=C2)C3=C4C(C=CC(C5=CN=C(C=CC=C6)C6=C5)=C4)=NC=C3CO1
Molecular Formula
C30H22N4O2
Molecular Weight
470.52
Precautions
H302, H315, H319, H335
References & Citations
[1]Toledo LI, et al. A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations. Nat Struct Mol Biol. 2011 Jun;18 (6) :721-7.|[2]Teng PN, et al. Pharmacologic inhibition of ATR and ATM offers clinically important distinctions to enhancing platinum or radiation response in ovarian, endometrial, and cervical cancer cells. Gynecol Oncol. 2015 Mar;136 (3) :554-61.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ATM; ATR; mTOR
Available Sizes
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