ETP-46464

ETP-46464 is an effective mTOR and ATR inhibitor with IC50s of 0.6 and 14 nM, respectively.

Product Specifications

CAS Number

[1345675-02-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ATM/ATR; mTOR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/etp-46464.html

Purity

99.54

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

O=C1N(C2=CC=C(C(C)(C#N)C)C=C2)C3=C4C(C=CC(C5=CN=C(C=CC=C6)C6=C5)=C4)=NC=C3CO1

Molecular Formula

C30H22N4O2

Molecular Weight

470.52

Precautions

H302, H315, H319, H335

References & Citations

[1]Toledo LI, et al. A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations. Nat Struct Mol Biol. 2011 Jun;18 (6) :721-7.|[2]Teng PN, et al. Pharmacologic inhibition of ATR and ATM offers clinically important distinctions to enhancing platinum or radiation response in ovarian, endometrial, and cervical cancer cells. Gynecol Oncol. 2015 Mar;136 (3) :554-61.