GSK598809
Product Specifications
UNSPSC Description
GSK598809 is a potent and selective dopamine D3 Receptor (DRD3) antagonist, with a pKi of 8.9.
Target Antigen
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/GSK598809.html
Purity
99.74
Solubility
1M HCl : 28.57 mg/mL (ultrasonic;adjust pH to 2 with HCl)|DMSO : 83.33 mg/mL (ultrasonic)
Smiles
CC1=C(C2=NN=C(SCCCN3CC4(C5=CC=C(C(F)(F)F)C=C5F)CC4C3)N2C)OC=N1
Molecular Weight
481.51
References & Citations
[1]Appel NM, et al. Dopamine D3 Receptor Antagonist (GSK598809) Potentiates the Hypertensive Effects of Cocaine in Conscious, Freely-Moving Dogs. J Pharmacol Exp Ther. 2015 Sep;354(3):484-92.|[2]Micheli F, et al. 1,2,4-Triazolyl azabicyclo[3.1.0]hexanes: a new series of potent and selective dopamine D(3) receptor antagonists. J Med Chem. 2010 Jan 14;53(1):374-91.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-19654/GSK598809-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-19654/GSK598809-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
863680-45-9
Available Sizes
Curated Selection
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