GSK598809
GSK598809 is a potent and selective dopamine D3 Receptor (DRD3) antagonist, with a pKi of 8.9.
Product Specifications
CAS Number
[863680-45-9]
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/GSK598809.html
Concentration
10mM
Purity
99.74
Solubility
1M HCl : 28.57 mg/mL (ultrasonic; adjust pH to 2 with HCl) |DMSO : 83.33 mg/mL (ultrasonic)
Smiles
CC1=C(C2=NN=C(SCCCN3CC4(C5=CC=C(C(F)(F)F)C=C5F)CC4C3)N2C)OC=N1
Molecular Formula
C22H23F4N5OS
Molecular Weight
481.51
References & Citations
[1]Appel NM, et al. Dopamine D3 Receptor Antagonist (GSK598809) Potentiates the Hypertensive Effects of Cocaine in Conscious, Freely-Moving Dogs. J Pharmacol Exp Ther. 2015 Sep;354 (3) :484-92.|[2]Micheli F, et al. 1,2,4-Triazolyl azabicyclo[3.1.0]hexanes: a new series of potent and selective dopamine D (3) receptor antagonists. J Med Chem. 2010 Jan 14;53 (1) :374-91.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
D3 Receptor
Available Sizes
Curated Selection
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