GSK598809

GSK598809 is a potent and selective dopamine D3 Receptor (DRD3) antagonist, with a pKi of 8.9.

Product Specifications

CAS Number

[863680-45-9]

UNSPSC

12352005

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/GSK598809.html

Concentration

10mM

Purity

99.74

Solubility

1M HCl : 28.57 mg/mL (ultrasonic; adjust pH to 2 with HCl) |DMSO : 83.33 mg/mL (ultrasonic)

Smiles

CC1=C(C2=NN=C(SCCCN3CC4(C5=CC=C(C(F)(F)F)C=C5F)CC4C3)N2C)OC=N1

Molecular Formula

C22H23F4N5OS

Molecular Weight

481.51

References & Citations

[1]Appel NM, et al. Dopamine D3 Receptor Antagonist (GSK598809) Potentiates the Hypertensive Effects of Cocaine in Conscious, Freely-Moving Dogs. J Pharmacol Exp Ther. 2015 Sep;354 (3) :484-92.|[2]Micheli F, et al. 1,2,4-Triazolyl azabicyclo[3.1.0]hexanes: a new series of potent and selective dopamine D (3) receptor antagonists. J Med Chem. 2010 Jan 14;53 (1) :374-91.