JAB-3068

SHP2-IN-6

JAB-3068 (SHP2-IN-6) is a potent SHP2 inhibitor, extracted from patent WO2017211303A1, compound 7, has an IC50 of 25.8 nM[1].

Phosphatase; SHP2

Reference compound

Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK

Cancer

https://www.medchemexpress.com/jab-3068.html

99.44

DMSO : 116.67 mg/mL (ultrasonic)

CC(N1CC(F)(F)C2=C1C=CC=C2SC3=NC=C(N(CC4)CCC54[C@H](N)COC5)N=C3N)=O

476.54

[1]Cunbo Ma, et al. Novel heterocyclic derivatives useful as shp2 inhibitors. WO2017211303A1.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-131132/JAB-3068-DataSheet-MedChemExpress.pdf

http://file.medchemexpress.com/batch_PDF/HY-131132/JAB-3068-SDS-MedChemExpress.pdf

Phase 2

2169223-48-5