SBI-425

SBI-425 is an orally active and potent TNAP (tissue-nonspecific alkaline phosphatase) inhibitor (IC50=16 nM) . SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival[1][2].

Product Specifications

CAS Number

[1451272-71-1]

UNSPSC

12352005

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/sbi-425.html

Purity

99.40

Solubility

DMSO : 86.67 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(NS(=O)(C2=CC(Cl)=CC=C2OC)=O)=CN=C1)N

Molecular Formula

C13H12ClN3O4S

Molecular Weight

341.77

References & Citations

[1]Pinkerton AB, et al. Discovery of 5- ((5-chloro-2-methoxyphenyl) sulfonamido) nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor. Bioorg Med Chem Lett. 2018 Jan 1;28 (1) :31-34.|[2]Sheen CR, et al. Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification. J Bone Miner Res. 2015 May;30 (5) :824-36.|[3]Brichacek AL, et al. Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis. Sci Rep. 2019 Dec 11;9 (1) :18788.