H-Gly-Pro-Gly-NH2

H-Gly-Pro-Gly-NH2 is a tripeptide that inhibits HIV-1 replication. H-Gly-Pro-Gly-NH2 inhibits the activity of HIV-1 IIIB and HIV-2 ROD with EC50 values of 35 µM and 30 µM, respectively. H-Gly Pro Gly NH2 inhibits HIV-1 replication in vitro by interfering with capsid formation. H-Gly Pro Gly NH2 has antiviral activity and can be used for virus research[1][2][3].

Product Specifications

CAS Number

[141497-12-3]

UNSPSC

12352209

Target

Amino Acid Derivatives; HIV

Type

Peptides

Related Pathways

Anti-infection; Others

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/h-gly-pro-gly-nh2.html

Solubility

10 mM in DMSO

Smiles

NC(CNC([C@H]1N(CCC1)C(CN)=O)=O)=O

Molecular Formula

C9H16N4O3

Molecular Weight

228.25

References & Citations

[1]Höglund S, et al. Tripeptide interference with human immunodeficiency virus type 1 morphogenesis. Antimicrob Agents Chemother. 2002 Nov;46 (11) :3597-605. |[2]Andersson E, et al. No cross-resistance or selection of HIV-1 resistant mutants in vitro to the antiretroviral tripeptide glycyl-prolyl-glycine-amide[J]. Antiviral research, 2004, 61 (2) : 119-124.|[3]Balzarini J, et al. Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH (2) ) . Int J Biochem Cell Biol. 2004 Sep;36 (9) :1848-59.