Sodium Picosulfate

Sodium Picosulfate (Sodium Picosulphate) is a contact irritant laxative with oral activity. Sodium Picosulfate inhibits the absorption of water and electrolytes, increasing their production. Sodium Picosulfate can be used in colonoscopy applications[1][2][3][4].

Product Specifications

CAS Number

[10040-45-6]

Product Name Alternative

Sodium Picosulphate

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Sodium-Picosulfate.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O=S(OC1=CC=C(C=C1)C(C2=CC=CC=N2)C3=CC=C(OS(=O)(O[Na])=O)C=C3)(O[Na])=O

Molecular Formula

C18H13NNa2O8S2

Molecular Weight

481.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Nishikawa J, et al. Toxicity study with sodium picosulfate in cultured liver cells of rabbit, rat and man. Arzneimittelforschung. 1981;31 (2) :321-5.|[2]Geboes K, et al. Effects of 'contact laxatives' on intestinal and colonic epithelial cell proliferation. Pharmacology. 1993 Oct;47 Suppl 1:187-95.|[3]Fioramonti J, et al. In vivo motility of rat colon chronically pretreated with sennosides. Pharmacology. 1993 Oct;47 Suppl 1:155-61.|[4]Regev A, et al. Comparison of two bowel preparations for colonoscopy: sodium picosulphate with magnesium citrate versus sulphate-free polyethylene glycol lavage solution. Am J Gastroenterol. 1998 Sep;93 (9) :1478-82.