Thiomyristoyl
Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM.
Product Specifications
CAS Number
[1429749-41-6]
UNSPSC
12352005
Hazard Statement
H302, H319, H332, H372, H400
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Thiomyristoyl.html
Purity
99.74
Solubility
DMSO : ≥ 32 mg/mL|Ethanol : 15.29 mg/mL (ultrasonic)
Smiles
O=C(OCC1=CC=CC=C1)N[C@H](C(NC2=CC=CC=C2)=O)CCCCNC(CCCCCCCCCCCCC)=S
Molecular Formula
C34H51N3O3S
Molecular Weight
581.85
Precautions
H302, H319, H332, H372, H400
References & Citations
[1]Jing H, et al. A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity. Cancer Cell. 2016 Mar 14;29 (3) :297-310.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT1; SIRT2
Available Sizes
Curated Selection
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