PHA 568487 (free base)
PHA 568487 free base is a selective alpha 7 nicotinic acetylcholine receptor (α-7 nAchR) agonist. PHA 568487 free base reduces neuroinflammation[1][2][3].
Product Specifications
CAS Number
527680-56-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pha-568487-free-base.html
Purity
99.29
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; adjust pH to 8 with HCl; heat to 80°C)
Smiles
O=C(C1=CC=C2C(OCCO2)=C1)N[C@@H]3C(CC4)CCN4C3
Molecular Formula
C16H20N2O3
Molecular Weight
288.35
Precautions
H302, H315, H319
References & Citations
[1]F Barclay Shilliday, et al. Multiple species metabolism of PHA-568487, a selective alpha 7 nicotinic acetylcholine receptor agonist. Drug Metab Lett. 2010 Aug;4 (3) :162-72. |[2]Zhenying Han, et al. Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture. J Neurochem. 2014 Nov;131 (4) :498-508. |[3]Lorena Colás, et al. In vivo imaging of Α7 nicotinic receptors as a novel method to monitor neuroinflammation after cerebral ischemia. Glia. 2018 Aug;66 (8) :1611-1624.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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