PHA 568487 (free base)

PHA 568487 free base is a selective alpha 7 nicotinic acetylcholine receptor (α-7 nAchR) agonist. PHA 568487 free base reduces neuroinflammation[1][2][3].

Product Specifications

CAS Number

[527680-56-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pha-568487-free-base.html

Purity

99.29

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; adjust pH to 8 with HCl; heat to 80°C)

Smiles

O=C(C1=CC=C2C(OCCO2)=C1)N[C@@H]3C(CC4)CCN4C3

Molecular Formula

C16H20N2O3

Molecular Weight

288.35

Precautions

H302, H315, H319

References & Citations

[1]F Barclay Shilliday, et al. Multiple species metabolism of PHA-568487, a selective alpha 7 nicotinic acetylcholine receptor agonist. Drug Metab Lett. 2010 Aug;4 (3) :162-72. |[2]Zhenying Han, et al. Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture. J Neurochem. 2014 Nov;131 (4) :498-508. |[3]Lorena Colás, et al. In vivo imaging of Α7 nicotinic receptors as a novel method to monitor neuroinflammation after cerebral ischemia. Glia. 2018 Aug;66 (8) :1611-1624.