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Anti-PRC1 Antibody (Phospho-Thr481)

Boster Bio Anti-PRC1 Antibody (Phospho-Thr481) catalog # A00160T481. Tested in ELISA, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Protein regulator of cytokinesis 1

Gene Name

PRC1

UniProt

O43663

Host

Rabbit

Reactivity

Human

Immunogen

Synthetic Phospho peptide from human protein at AA range: 481

Clonality

Polyclonal

Tissue Specificity

Overexpressed in bladder cancer cells (PubMed:17409436) .

Applications

WB, ELISA

Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436) .

Molecular Weight

71607 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A00160T481

Product MSDS

https://www.bosterbio.com/msds?sku=A00160T481

Fragment

IgG

Other Gene Names

Protein regulator of cytokinesis 1

Subcellular Location

Nucleus

Protein Name

Protein regulator of cytokinesis 1

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