Anti-PRC1 Antibody (Phospho-Thr481)
Boster Bio Anti-PRC1 Antibody (Phospho-Thr481) catalog # A00160T481. Tested in ELISA, WB applications. This antibody reacts with Human.
Product Specifications
Synonyms
Protein regulator of cytokinesis 1
Gene Name
PRC1
UniProt
O43663
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic Phospho peptide from human protein at AA range: 481
Clonality
Polyclonal
Tissue Specificity
Overexpressed in bladder cancer cells (PubMed:17409436) .
Applications
WB, ELISA
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration
1 mg/ml
Form
Liquid
Function
Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436) .
Molecular Weight
71607 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
Protein regulator of cytokinesis 1
Subcellular Location
Nucleus
Protein Name
Protein regulator of cytokinesis 1
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