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Anti-Smad6 Monoclonal Antibody

Boster Bio Anti-Smad6 Monoclonal Antibody catalog # M02227. Tested in ELISA, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Mothers against decapentaplegic homolog 6; MAD homolog 6; Mothers against DPP homolog 6; SMAD family member 6; SMAD 6; Smad6; hSMAD6; SMAD6; MADH6;

Gene Name

SMAD6

UniProt

O43541

Host

Mouse

Reactivity

Human

Immunogen

Purified recombinant fragment of human Smad6 expressed in E. Coli.

Clonality

Monoclonal

Clone

Clone: 5H3

Tissue Specificity

Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.

Applications

WB, ELISA

Purification

Affinity purification

Concentration

1 mg/ml

Form

Liquid

Function

Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.

Molecular Weight

53497 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Mothers against decapentaplegic homolog 6

Subcellular Location

Nucleus

Protein Name

Mothers against decapentaplegic homolog 6

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