Anti-SARS-E2 Monoclonal Antibody

Boster Bio Anti-SARS-E2 Monoclonal Antibody catalog # M00501. Tested in ELISA, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Serine--tRNA ligase, cytoplasmic;6.1.1.11

Gene Name

SARS

UniProt

P49591

Host

Mouse

Reactivity

Human

Immunogen

Purified recombinant fragment of SARS-E2 glycoprotein precursor expressed in E. Coli.

Clonality

Monoclonal

Clone

Clone: 4A6C9

Tissue Specificity

Brain.

Applications

WB, ELISA

Purification

Affinity purification

Concentration

1 mg/ml

Form

Liquid

Function

Catalyzes the attachment of serine to tRNA (Ser) in a two-step reaction: serine is first activated by ATP to form Ser- AMP and then transferred to the acceptor end of tRNA (Ser) (PubMed:22353712, PubMed:24095058, PubMed:9431993, PubMed:26433229, PubMed:28236339) . Is probably also able to aminoacylate tRNA (Sec) with serine, to form the misacylated tRNA L-seryl-tRNA (Sec), which will be further converted into selenocysteinyl-tRNA (Sec) (PubMed:9431993, PubMed:26433229, PubMed:28236339) . In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000) . Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16) . Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000) .