Anti-Rtn-3 Monoclonal Antibody
Boster Bio Anti-Rtn-3 Monoclonal Antibody catalog # M03760. Tested in ELISA, IHC applications. This antibody reacts with Human.
Product Specifications
Synonyms
Reticulon-3; Homolog of ASY protein; HAP; Neuroendocrine-specific protein-like 2; NSP-like protein 2; Neuroendocrine-specific protein-like II; NSP-like protein II; NSPLII; RTN3; ASYIP, NSPL2;
Gene Name
RTN3
UniProt
O95197
Host
Mouse
Reactivity
Human
Immunogen
Purified recombinant fragment of Rtn-3 expressed in E. Coli.
Clonality
Monoclonal
Clone
Clone: 10A8
Tissue Specificity
Isoform 3 is widely expressed, with highest levels in brain, where it is enriched in neuronal cell bodies from gray matter (at protein level) . Three times more abundant in macula than in peripheral retina. Isoform 1 is expressed at high levels in brain and at low levels in skeletal muscle. Isoform 2 is only found in melanoma.
Applications
IHC, ELISA
Purification
Affinity purification
Concentration
1 mg/ml
Form
Liquid
Function
May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671) .
Molecular Weight
112611 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=M03760
Product MSDS
https://www.bosterbio.com/msds?sku=M03760
Fragment
IgG
Other Gene Names
Reticulon-3
Subcellular Location
Endoplasmic reticulum membrane
Protein Name
Reticulon-3
Curated Selection
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