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Anti-ROR1 Monoclonal Antibody

Boster Bio Anti-ROR1 Monoclonal Antibody catalog # M03192. Tested in ELISA, IF, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Inactive tyrosine-protein kinase transmembrane receptor ROR1 ; Neurotrophic tyrosine kinase, receptor-related 1; ROR1; NTRKR1;

Gene Name

ROR1

UniProt

Q01973

Host

Mouse

Reactivity

Human

Immunogen

Recombinant extracellular fragment of human ROR1 (aa30-406) fused with hIgGFc tag, expressed in HEK293 cells

Clonality

Monoclonal

Clone

Clone: 2H6

Tissue Specificity

Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.

Applications

WB, IF, ELISA

Purification

Affinity purification

Concentration

1 mg/ml

Form

Liquid

Function

Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443) . Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350) . In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350) .

Molecular Weight

104283 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Inactive tyrosine-protein kinase transmembrane receptor ROR1

Subcellular Location

Membrane

Protein Name

Inactive tyrosine-protein kinase transmembrane receptor ROR1

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