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Anti-Rictor Monoclonal Antibody

Boster Bio Anti-Rictor Monoclonal Antibody catalog # M03195. Tested in ELISA, Flow Cytometry, IF, IHC, WB applications. This antibody reacts with Human, Monkey, Mouse.

Product Specifications

Synonyms

Rapamycin-insensitive companion of mTOR; AVO3 homolog; hAVO3; RICTOR

Gene Name

RICTOR

UniProt

Q6R327

Host

Mouse

Reactivity

Human, Mouse, Monkey

Immunogen

Purified recombinant fragment of human Rictor expressed in E. Coli.

Clonality

Monoclonal

Clone

Clone: 7B3

Applications

WB, IHC, IF, Flow Cytometry, ELISA

Purification

Affinity purification

Concentration

1 mg/ml

Form

Liquid

Function

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.

Molecular Weight

192218 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Rapamycin-insensitive companion of mTOR

Protein Name

Rapamycin-insensitive companion of mTOR

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