Anti-Kelch-like protein 25 KLHL25 Monoclonal Antibody
Boster Bio Anti-Kelch-like protein 25 KLHL25 Monoclonal Antibody catalog # M14745. Tested in ELISA, WB applications. This antibody reacts with Human.
Product Specifications
Synonyms
Kelch-like protein 25; Ectoderm-neural cortex protein 2; ENC-2; KLHL25; ENC2;
Gene Name
KLHL25
UniProt
Q9H0H3
Host
Mouse
Reactivity
Human
Immunogen
Purified recombinant fragment of human KLHL25 expressed in E. Coli.
Clonality
Monoclonal
Clone
Clone: 1B7
Applications
WB, ELISA
Purification
Affinity purification
Concentration
1 mg/ml
Form
Liquid
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR (KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1) : ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR (KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.
Molecular Weight
65923 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
Kelch-like protein 25
Protein Name
Kelch-like protein 25
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