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Anti-FGF-2 Monoclonal Antibody

Boster Bio Anti-FGF-2 Monoclonal Antibody catalog # M00121-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Fibroblast growth factor 2; FGF-2; Basic fibroblast growth factor; bFGF; Heparin-binding growth factor 2; HBGF-2; FGF2; FGFB;

Gene Name

FGF2

UniProt

P09038

Host

Mouse

Reactivity

Human

Immunogen

Purified recombinant fragment of FGF-2 expressed in E. Coli.

Clonality

Monoclonal

Clone

Clone: 2H5G2C11

Tissue Specificity

Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non- cancerous liver tissue.

Applications

WB, IHC, ELISA

Purification

Affinity purification

Concentration

1 mg/ml

Form

Liquid

Function

Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044) . Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677) . Binds to integrin ITGAV:ITGB3 (PubMed:28302677) . Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:8663044, PubMed:28302677) . Functions as a potent mitogen in vitro (PubMed:3732516, PubMed:3964259) . Can induce angiogenesis (PubMed:23469107, PubMed:28302677) .

Molecular Weight

30770 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Other Gene Names

Fibroblast growth factor 2

Subcellular Location

Secreted. Nucleus. Exported from cells by an endoplasmic reticulum (ER) /Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57.

Protein Name

Fibroblast growth factor 2

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