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Anti-ErbB-3 Monoclonal Antibody

Boster Bio Anti-ErbB-3 Monoclonal Antibody catalog # M00539-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Receptor tyrosine-protein kinase erbB-3;2.7.10.1; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3; ERBB3; HER3;

Gene Name

ERBB3

UniProt

P21860

Host

Mouse

Reactivity

Human

Immunogen

Purified recombinant fragment of ErbB-3 (aa1175-1275) expressed in E. Coli.

Clonality

Monoclonal

Clone

Clone: 3F10F6

Tissue Specificity

Epithelial tissues and brain.

Applications

WB, IHC, ELISA

Purification

Affinity purification

Concentration

1 mg/ml

Form

Liquid

Function

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778) . May also be activated by CSPG5 (PubMed:15358134) .

Molecular Weight

148098 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Receptor tyrosine-protein kinase erbB-3

Subcellular Location

Isoform 1: Cell membrane; Single-pass type I membrane protein.

Protein Name

Receptor tyrosine-protein kinase erbB-3

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