Anti-CD166 ALCAM Monoclonal Antibody

Detected on hematopoietic stem cells derived from umbilical cord blood (PubMed:24740813) . Detected on lymph vessel endothelial cells, skin and tonsil (PubMed:23169771) . Detected on peripheral blood monocytes (PubMed:15048703) . Detected on monocyte-derived dendritic cells (at protein level) (PubMed:16352806) . Detected at low levels in spleen, placenta, liver (PubMed:9502422) . Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells (PubMed:7760007) . Isoform 1 and isoform 3 are detected in vein and artery endothelial cells, astrocytes, keratinocytes and artery smooth muscle cells (PubMed:15496415) . Expressed by neurons in the brain. Restricted expression in tumor cell lines. Detected in highly metastasizing melanoma cell lines (PubMed:9502422) .

Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:7760007, PubMed:15496415, PubMed:15048703, PubMed:16352806, PubMed:23169771, PubMed:24945728) . Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728) . Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806) . Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806) . Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813) . Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771) . Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771) . Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity) . Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity) .