Anti-HIF-1 beta/ARNT Monoclonal Antibody

Boster Bio Anti-HIF-1 beta/ARNT Monoclonal Antibody catalog # M02263-1. Tested in IHC, WB applications. This antibody reacts with Mouse.

Product Specifications

Synonyms

Aryl hydrocarbon receptor nuclear translocator; ARNT protein; Class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor, nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta; ARNT; BHLHE2;

Gene Name

ARNT

UniProt

P27540

Host

Mouse

Reactivity

Mouse

Immunogen

Recombinant Protein of HIF-1 β

Clonality

Monoclonal

Clone

Clone: 4C5

Applications

WB, IHC

Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity) . The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409) .