Anti-TBP/TATA Binding Protein Monoclonal Antibody

Boster Bio Anti-TBP/TATA Binding Protein Monoclonal Antibody catalog # M00302-1. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

TATA-box-binding protein; TATA sequence-binding protein; TATA-binding factor

Gene Name

TBP

UniProt

P20226

Host

Mouse

Reactivity

Human, Rat, Mouse

Immunogen

Recombinant Protein of TBP/TATA Binding Protein

Clonality

Monoclonal

Clone

Clone: 1F6

Tissue Specificity

Widely expressed, with levels highest in the testis and ovary.

Applications

IHC

Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Concentration

1 mg/ml

Dilution

IHC 1:50-200

Form

Liquid

Function

General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682) . Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682) . Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III (PubMed:26638071) . Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription (PubMed:15970593) . The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.