Anti-CD6 Antibody

Detected on thymocytes (PubMed:15294938) . Detected on peripheral blood T-cells (PubMed:15048703, PubMed:16352806) . Detected on natural killer (NK) cells (PubMed:16352806) . Soluble CD6 is detected in blood serum (at protein level) (PubMed:17601777) . Detected in spleen, thymus, appendix, lymph node and peripheral blood leukocytes (PubMed:9013954) . Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.

Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089) . Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089) . Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752) . Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806) . Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777) . LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777) . Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777) .