Anti-Histone H2B (Phospho-Ser32) HIST1H2BA Antibody

Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (By similarity) . Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (By similarity) . Core component of nucleosome (By similarity) . Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (By similarity) . Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (By similarity) . DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity) . Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear (PubMed:21249133) .