Anti-ABCB5 Monoclonal Antibody

Boster Bio Anti-ABCB5 Monoclonal Antibody catalog # M02979. Tested in WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

ATP-binding cassette sub-family B member 5; ABCB5 P-gp; P-glycoprotein ABCB5; ABCB5;

Gene Name

ABCB5

UniProt

Q2M3G0

Host

Mouse

Reactivity

Human

Immunogen

Synthetic Peptide of ABCB5

Clonality

Monoclonal

Clone

Clone: 11A2

Tissue Specificity

Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level) . Widely expressed with specific expression in pigment cells. Highly expressed in several malignant tissues: highly expressed in clinical melanomas, with low expression in normal skin. In melanoma, marks malignant melanoma-initiating cells (MMIC), in which clinical virulence resides as a consequence of unlimited self-renewal capacity, resulting in inexorable tumor progression and metastasis. Also highly expressed in a number of leukemia cells. Expressed in basal limbal epithelium.

Applications

Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Concentration

1 mg/ml

Dilution

WB 1:2000

Form

Liquid

Function

Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair.