Anti-Ki 67 MKI67 Monoclonal Antibody

Boster Bio Anti-Ki 67 MKI67 Monoclonal Antibody catalog # M00254-7. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Proliferation marker protein Ki-67 ; Antigen identified by monoclonal antibody Ki-67

Gene Name

MKI67

UniProt

P46013

Host

Mouse

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic Peptide of Ki 67

Clonality

Monoclonal

Clone

Clone: 4A8

Applications

IHC

Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Concentration

1 mg/ml

Dilution

IHC 1:200

Form

Liquid

Function

Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226) . Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226) . Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226) . Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551) . Does not contribute to the internal structure of mitotic chromosomes (By similarity) . May play a role in chromatin organization (PubMed:24867636) . It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable) .