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Anti-CD169 SIGLEC1 Antibody

Boster Bio Anti-CD169 SIGLEC1 Antibody catalog # A05186. Tested in ELISA, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Sialoadhesin; Sialic acid-binding Ig-like lectin 1; Siglec-1; CD169; SIGLEC1; SN;

Gene Name

SIGLEC1

UniProt

Q9BZZ2

Host

Rabbit

Reactivity

Human

Immunogen

The antiserum was produced against synthesized peptide derived from the Internal region of human SIGLEC1. AA range:1321-1370

Clonality

Polyclonal

Tissue Specificity

Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis.

Applications

WB, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity) . Binds to SPN/CD43 on T-cells (By similarity) . May play a role in hemopoiesis. .

Molecular Weight

182624 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Sialoadhesin

Subcellular Location

Isoform 1: Cell membrane; Single-pass type I membrane protein.

Protein Name

Sialoadhesin

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