Nutlin carboxylic acid
Nutlin carboxylic acid is the Nutlin 3-based MDM2 ligand. Nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTAC[1].
Product Specifications
CAS Number
[2249750-27-2]
Product Name Alternative
MDM2 ligand 1; E3 ligase Ligand 16
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e3-ligase-ligand-16.html
Purity
98.63
Solubility
DMSO : 50 mg/mL (ultrasonic; warming)
Smiles
O=C(N1CC(N(CC1)CC(O)=O)=O)N2C(C3=C(OC(C)C)C=C(OC)C=C3)=N[C@H]([C@H]2C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5
Molecular Formula
C32H32Cl2N4O6
Molecular Weight
639.53
Precautions
H302, H315, H319, H335
References & Citations
[1]Li G, et al. A PARP1 PROTAC as a novel strategy against PARP inhibitor resistance via promotion of ferroptosis in p53-positive breast cancer. Biochem Pharmacol. 2022 Dec;206:115329.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MDM2
Available Sizes
Curated Selection
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