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Anti-CKR-4 CCR4 Antibody

Boster Bio Anti-CKR-4 CCR4 Antibody catalog # A00755-3. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

C-C chemokine receptor type 4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4; K5-5; CD194; CCR4; CMKBR4;

Gene Name

CCR4

UniProt

P51679

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from the N-terminal region of human CCR4. AA range:1-50

Clonality

Polyclonal

Tissue Specificity

Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA) . Expressed in brain microvascular and coronary artery endothelial cells.

Applications

WB, IHC, ELISA

Purification

The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.

Concentration

1 mg/ml

Form

Liquid

Function

High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G (i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

Molecular Weight

41403 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

C-C chemokine receptor type 4

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Name

C-C chemokine receptor type 4

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