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Anti-Keap1 Antibody

Boster Bio Anti-Keap1 Antibody catalog # A00514-2. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Kelch-like ECH-associated protein 1; Cytosolic inhibitor of Nrf2; INrf2; Kelch-like protein 19; KEAP1; INRF2, KIAA0132, KLHL19;

Gene Name

KEAP1

UniProt

Q14145

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from the Internal region of human KEAP1. AA range:411-460

Clonality

Polyclonal

Tissue Specificity

Broadly expressed, with highest levels in skeletal muscle.

Applications

WB, IHC, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.

Molecular Weight

69666 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Kelch-like ECH-associated protein 1

Subcellular Location

Cytoplasm. Nucleus. Shuttles between cytoplasm and nucleus.

Protein Name

Kelch-like ECH-associated protein 1

Frequently Asked Questions

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