Anti-MK MDK Antibody

Boster Bio Anti-MK MDK Antibody catalog # A01823-2. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Rat.

Product Specifications

Synonyms

Midkine; MK; Amphiregulin-associated protein; ARAP; Midgestation and kidney protein; Neurite outgrowth-promoting factor 2; Neurite outgrowth-promoting protein; MDK; MK1, NEGF2;

Gene Name

MDK

UniProt

P21741

Host

Rabbit

Reactivity

Human, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from the Internal region of human MDK. AA range:94-143

Clonality

Polyclonal

Tissue Specificity

Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions.

Applications

WB, IHC, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity) .