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Anti-5'-3' exoribonuclease 2 XRN2 Antibody

Boster Bio Anti-5'-3' exoribonuclease 2 XRN2 Antibody catalog # A02797-2. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Monkey, Mouse.

Product Specifications

Synonyms

5'-3' exoribonuclease 2;3.1.13.-; DHM1-like protein; DHP protein; XRN2;

Gene Name

XRN2

UniProt

Q9H0D6

Host

Rabbit

Reactivity

Human, Mouse, Monkey

Immunogen

The antiserum was produced against synthesized peptide derived from human XRN2. AA range:81-130

Clonality

Polyclonal

Tissue Specificity

Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes.

Applications

ELISA, IHC, WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Possesses 5'->3' exoribonuclease activity (By similarity) . May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224) .

Molecular Weight

108582 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A02797-2

Product MSDS

https://www.bosterbio.com/msds?sku=A02797-2

Fragment

IgG

Other Gene Names

5'-3' exoribonuclease 2

Subcellular Location

Nucleus, nucleolus

Protein Name

5'-3' exoribonuclease 2

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