Anti-UBN-1 Antibody

Boster Bio Anti-UBN-1 Antibody catalog # A07807. Tested in ELISA, IF, IHC applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

Ubinuclein-1; HIRA-binding protein; Protein VT4; Ubiquitously expressed nuclear protein; UBN1;

Gene Name

UBN1

UniProt

Q9NPG3

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human Ubinuclein. AA range:161-210

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. Also expressed in numerous tumors and cancer cell lines.

Applications

IHC, IF, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication- independent chromatin assembly.

Molecular Weight

121520 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Ubinuclein-1

Subcellular Location

Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis.