Anti-TRAC-1 RNF125 Antibody

Predominantly expressed in lymphoid tissues, including bone marrow, spleen and thymus. Also weakly expressed in other tissues. Predominant in the CD4 (+) and CD8 (+) T-cells, suggesting that it is preferentially confined to T-cells.

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53 (PubMed:15843525, PubMed:17460044, PubMed:17643463, PubMed:26027934, PubMed:26471729, PubMed:25591766, PubMed:27411375) . Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at 'Lys-181', leading to DDX58/RIG-I degradation (PubMed:17460044, PubMed:26471729) . Mediates ubiquitination and subsequent degradation of p53/TP53 (PubMed:25591766) . Mediates ubiquitination and subsequent degradation of JAK1 (PubMed:26027934) . Acts as a positive regulator of T-cell activation (PubMed:15843525) .