Anti-Transcription factor RFX3 RFX3 Antibody
Boster Bio Anti-Transcription factor RFX3 RFX3 Antibody catalog # A07674-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
Transcription factor RFX3; Regulatory factor X 3; RFX3;
Gene Name
RFX3
UniProt
P48380
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human RFX3. AA range:641-690
Clonality
Polyclonal
Applications
WB, IHC, ELISA
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Form
Liquid
Function
Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left- right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity) . Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes (PubMed:20148032) . Represses transcription of MAP1A in non- neuronal cells but not in neuronal cells (PubMed:12411430) .
Molecular Weight
83530 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
Transcription factor RFX3
Subcellular Location
Nucleus .
Protein Name
Transcription factor RFX3
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