Anti-NCKX6 SLC8B1 Antibody

Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928) . Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity) . Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385) . Required for store-operated Ca (2+) entry (SOCE) and Ca (2+) release-activated Ca (2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928) . Involved in B-lymphocyte chemotaxis (By similarity) . Able to transport Ca (2+) in exchange of either Li (+) or Na (+), explaining how Li (+) catalyzes Ca (2+) exchange (PubMed:15060069) . In contrast to other members of the family its function is independent of K (+) (PubMed:15060069) .