Anti-MRTF-A MKL1 Antibody
Boster Bio Anti-MRTF-A MKL1 Antibody catalog # A01157. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
MKL/myocardin-like protein 1; Basic SAP coiled-coil transcription activator; Megakaryoblastic leukemia 1 protein homolog; Myocardin-related transcription factor A; MRTF-A; Mkl1; Bsac;
Gene Name
MKL1
UniProt
Q8K4J6
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human MKL1. AA range:10-59
Clonality
Polyclonal
Tissue Specificity
Expressed in heart, brain, spleen, lung, liver, muscle, kidney and testis.
Applications
WB, IHC, ELISA
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Form
Liquid
Function
Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation.
Molecular Weight
102546 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
MKL/myocardin-like protein 1
Subcellular Location
Cytoplasm. Nucleus. Binding to globular actin is required to maintain cytoplasmic localization. Nuclear localization is regulated by MICAL2, which mediates depolymerization of nuclear globular actin, promoting retention of MKL1 in the nucleus and subsequent formation of an active complex with SRF (By similarity) . .
Protein Name
MKL/myocardin-like protein 1
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